Osteoarthritis (OA) is a leading cause of disability characterized by proteoglycan loss and collagen matrix disruption in the cartilage. Quantitative T1ρ and T2 mapping obtained in a static setting have been proposed to detect the biochemical changes associated with OA, which however lack the functional information of the cartilage. We here present a novel dynamic approach to elucidate biochemical recovery of knee cartilage after stair-climbing exercise with high-spatiotemporal-resolution simultaneous 3D T1ρ and T2 mapping. It could serve as an innovative, clinically feasible imaging biomarker to evaluate both biochemical and functional properties of cartilage for early OA diagnosis and prognosis.
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