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Abstract #4947

Dynamic T1ρ and T2 mapping of Articular Cartilage Biochemical Recovery Post-exercise with 3T MRI

Jason Matakas1, Steven Shamah1, Esther Rong1, Jenna Le1, Karen Sperling1, Can Wu2, and Qi Peng1
1Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States, 2Memorial Sloan Kettering Cancer Center, New York, NY, United States

Synopsis

Osteoarthritis (OA) is a leading cause of disability characterized by proteoglycan loss and collagen matrix disruption in the cartilage. Quantitative T1ρ and T2 mapping obtained in a static setting have been proposed to detect the biochemical changes associated with OA, which however lack the functional information of the cartilage. We here present a novel dynamic approach to elucidate biochemical recovery of knee cartilage after stair-climbing exercise with high-spatiotemporal-resolution simultaneous 3D T1ρ and T2 mapping. It could serve as an innovative, clinically feasible imaging biomarker to evaluate both biochemical and functional properties of cartilage for early OA diagnosis and prognosis.

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Keywords