High susceptibility levels at the marrow/bone interface may significantly reduce T2* of marrow, leading to trabecular bone volume overestimation when imaged using conventional MRI sequences. The presence of fat in bone marrow further complicates trabecular bone imaging due to chemical shift artifacts. In this study, an ultrashort echo time MRI (UTE-MRI) technique focused on the fat peak frequency was investigated to image trabecular bone ex vivo and in vivo. This technique was shown to improve trabecular bone imaging by minimizing chemical shift artifacts as well as susceptibility related short T2* effects, thereby providing more accurate estimation of trabecular bone structure.
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