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Abstract #4950

3T Chemical Shift encoded MRI detects Bone Marrow Adipose Tissue changes In Osteoporosis with Fragility Fracture 

Dimitri Martel1, Benjamin Leporq2, Anmol Monga1, Stephen Honig3, and Gregory Chang1
1Radiology, NYU Langone Health, New York, NY, United States, 2Université de Lyon; CREATIS CNRS UMR 5220, Inserm U1206, INSA-Lyon, Villeurbanne, France, 3Osteoporosis Center, Hospital for Joint Diseases, NYU Langone Health, New York, NY, United States

Synopsis

Osteoporosis (OP) is associated with low bone mass and deterioration of bone tissue microarchitecture leading to increased bone fragility and fracture risk. There are increasing pieces of evidence that bone marrow adipose tissues (BMAT) play a significant role in the pathophysiology of osteoporosis. Our aim was to assess the proximal femur BMAT composition in OP without (OP) and with history of fragility fracture (OP-Fx) and compare it to naive controls using Chemical Shift Encoded MRI.

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