Abstract #4954

Structural covariance of diffusion metrics in mild COVID19: Spatially coherent effect on fractional anisotropy but not free water.

Nick Teller¹, Jordan A. Chad^1,2, Eugenie Roudaia¹, Ali Hashemi³, Haddas Grosbein¹, Asaf Gilboa^1,2, Maged Goubran^2,4, Ivy Cheng^2,4, Sandra E. Black^2,4, Robert Fowler^2,4, Chris Heyn^2,4, Fuqiang Gao⁴, Mario Masellis^2,4, Jennifer Rabin^2,4, Xiang Ji⁴, Aravinthan Jegatheesan^2,4, Benjamin Lam^2,4, Allison B. Sekuler^1,2,3, Bradley J. MacIntosh^2,4, Simon J. Graham^2,4, and J. Jean Chen^1,2

¹Rotman Research Institute, North York, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada, ⁴Sunnybrook Research Institute, Toronto, ON, Canada

Synopsis

The impact of COVID19 on the brain’s microstructural integrity remains unclear. In this study, we examine self-isolated COVID19 patients and controls using diffusion-tensor and free-water imaging, based on single- and multi-shell acquisitions, respectively. We identify several differences in spatial covariance among patients in fractional anisotropy (in cingulate-frontal and temporal-parietal regions), but not free water fraction. Our results indicate COVID19’s implications in long-term, measurable brain deficits.

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