Abstract #4953

Bone marrow fat quantification on vertebral and lower extremities using in-vivo MR spectroscopy: diabetes patients v.s healthy control

Po-hung Wu¹, Kaipin Xu², Gabby Joseph¹, Yan Li¹, Xiaojuan Li², Thomas Link¹, and Galateia Kazakia¹

¹Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States, ²Biomedical Engineering, Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States

Synopsis

Patients with type II diabetes (T2D) have increased fracture risk. Increased bone marrow fat is associated with increased fracture risk. We hypothesized that T2D patients will have altered bone marrow fat (BMF) and marrow composition biomarkers. In this study, we performed magnetic resonance spectroscopy (MRS) to quantify BMF and composition biomarkers at the spine in 37 T2D patients and 36 controls, and at the distal tibia in 30 T2D patients 32 controls. The results suggest that T2D may change vertebral marrow composition, particularly in men, which may be a factor in the development of increased bone fragility related to T2D.

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