Abstract #4952

Bone-marrow fatty-acids profiles from women calcaneus by 1H-MR Spectroscopy to search early osteoporotic biomarkers

Daniele Mattioli¹, Vincenzo Vinicola², Marco Montuori³, Umberto Tarantino⁴, and Silvia Capuani⁵

¹Physics Dpt., Sapienza University of Rome, Rome, Italy, ²Center for Prevention, Diagnosis and Treatment of Osteoporosis, IRCCS Santa Lucia Foundation, Rome, Italy, ³Institute for Complex Systems, National Research Council CNR-ISC, Rome, Italy, ⁴Department of Orthopaedics and Traumatology, Tor Vergata University of Rome, Rome, Italy, ⁵Institute for Complex Systems, National Research Council CNR-ISC, Roma, Italy

Synopsis

Changes occurring in the bone-marrow fatty-acids (BMFA) could be precursors of the bone mineral loss due to the development of osteoporosis. In this view, early biomarkers of osteoporosis among BMFA could be highlighted by quantifying fatty-acids with 1H-MRS in young, premenopausal, postmenopausal women with normal t-score and in osteoporotic women. In this study, L13, L09, fUFA, and fPUFA together with TL quantification obtained in women calcanei could be early osteoporosis markers. The present work confirms the potential of MRS to investigate BMFA metabolic variations due to postmenopause and to the development of osteoporosis.

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