Changes occurring in the bone-marrow fatty-acids (BMFA) could be precursors of the bone mineral loss due to the development of osteoporosis. In this view, early biomarkers of osteoporosis among BMFA could be highlighted by quantifying fatty-acids with 1H-MRS in young, premenopausal, postmenopausal women with normal t-score and in osteoporotic women. In this study, L13, L09, fUFA, and fPUFA together with TL quantification obtained in women calcanei could be early osteoporosis markers. The present work confirms the potential of MRS to investigate BMFA metabolic variations due to postmenopause and to the development of osteoporosis.
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