Abstract #4960
Evidence of meningeal inflammation in multiple sclerosis: a combined in vivo 11C-PBR28 MR-PET and post-mortem study
Elena Herranz1,2, Valeria Barletta1,2, Constantina A. Treaba1,2, Ambica Mehendiratta1, Russell Ouellette1,3,4, Eric Klawiter5,6, Jacob Sloane 2,7, Carolina Ionette8, Suma Babu2,5, Marco L. Loggia1,2, Meena M Makary1,2,9, Jacob M Hooker1,2, Ciprian Catana1,2, Revere Kinkel10, Roberta Magliozzi11,12, and Caterina Mainero1,2
1Radiology, Massachusetts General Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 4Department of Neurology, 4. Karolinska University Hospital, Stockholm, Sweden, 5Neurology, Massachusetts General Hospital, Boston, MA, United States, 6Massachusetts General Hospital, Boston, MA, United States, 7Beth Israel Deaconess Medical Center, Boston, MA, United States, 8Department of Neurology, UMass Memorial Medical Center, Worcester, MA, United States, 9Systems and Biomedical Engineering Department, Faculty of Engineering, Cairo University, Giza, Egypt, 10Department of Neuroscience, University of California, San Diego, CA, United States, 11Neurology Section, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy, 12Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, United Kingdom
Synopsis
In multiple sclerosis (MS), neuropathological studies suggest that meningeal inflammation involving T-, B-lymphocytes, plasma cells, macrophages may trigger underlying cortical neuroinflammation and demyelination. Using MR-PET targeting the18kDa mitochondrial translocator protein, which is overexpressed in activated glia/macrophages, we detected in 49 MS patients cortical inflammatory changes along with neuroinflammation in both meninges and juxtacortical white matter. Meningeal inflammation correlated with worse neurological disability and cognitive performance. Histochemistry performed in meningeal tissue from 40 post-mortem progressive MS cases confirmed in vivo findings. This study provides in vivo PET imaging evidence implicating meningeal neuroinflammation in the pathophysiology of MS.
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