Abstract #4961

Parameters associated with durable clinical success in a multi-center trial using MR guided focused ultrasound treat uterine leiomyomas

Rachel Bitton¹, Angela Fast², Gina Hesley³, Steven Raman⁴, Alan Matsumoto⁵, Eric Dolan⁶, Maureen Kohi⁷, Thomas Price⁸, Fiona Fenessey⁹, and Pejman Ghanouni¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Allegheny Health Network, Pittsburgh, PA, United States, ³Radiology, Mayo Clinic, Rochester, MN, United States, ⁴Radiology, UCLA, Los Angeles, CA, United States, ⁵Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, ⁶Interventional Radiology, Ohio Health, Columbus, OH, United States, ⁷Radiology, UCSF, San Francisco, CA, United States, ⁸Obstetrics and Gynecology, Duke University, Durham, NC, United States, ⁹Radiology, Brigham and Women's Hospital, Boston, MA, United States

Synopsis

This study presents results of a prospective multicenter clinical trial of 99 women treated with MR guided focused ultrasound (MRgFUS) for symptomatic uterine leiomyomas to assess treatment durability and to evaluate potential demographic, imaging, and technical characteristics associated with lasting clinical outcomes. Following treatment, there was an improvement in symptoms, with a significant decrease in mean symptom severity score at the 6, 12, 24 and 36 month follow up (p<0.001). In a multivariate model, a new parameter of interest, the ratio of non-perfused volume to total fibroid volume (NPV/TFV) was found to be predictive of durable clinical success (p=0.03).

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