Mild traumatic injury (mTBI) patients exhibit acute symptoms including headaches and memory problems that sometimes persist for months, though CT/MRI scans appear normal. The purpose of this study was to identify functional biomarkers of mTBI during the 3-months following injury using seed-based functional connectivity derived from multi-echo resting state functional MRI. In this work, we use multi-band multi-echo resting state fMRI to estimate seed-based functional connectivity. We propose a novel quantitative analysis methodology of suitable for voxel-wise single-subject assessment of disrupted functional connectivity by using an outlier-analysis approach.
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