Anatomical T1-weighted imaging allows us to examine relationships of regional morphology across the brain through structural covariance. Here, we investigated structural covariance stability using decreasing amounts of T1-weighted imaging data from the UK Biobank. Starting from 1,753 individuals, we found that it is possible to drastically reduce the sample and still maintain adequate stability (78% agreement with ~87 individuals). We note, however, that stability was regionally variable; lateral and cortical regions were least affected by sample size while medial and subcortical regions were most affected. These findings may inform sample size considerations for MRI-based structural covariance in large population studies.
This abstract and the presentation materials are available to members only; a login is required.