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Abstract #4999

MR T1ρ preparations: B1 and B0 inhomogeneity and T2ρ evaluation with Bloch equation-based simulation

Jeehun Kim1,2,3, Qi Peng4, Can Wu5, and Xiaojuan Li1,2,6
1Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, 2Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States, 3Department of Electrical Engineering, Case Western Reserve University, Cleveland, OH, United States, 4Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States, 5Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 6Department of Diagnostic Radiology, Cleveland Clinic, Cleveland, OH, United States

Synopsis

Quantitative T1ρ mapping is a promising biomarker for detecting tissue compositional changes at early stages of diseases. For reliable and reproducible measurements, T1ρ preparation pulses should be robust to B0 and B1 inhomogeneity. In this work, a Bloch equation based numerical simulation tool was developed and validated. The performance of six different T1ρ preparation schemes were evaluated in terms of their responses to B0 and B1 inhomogeneities using the simulation tool and in phantoms and human subjects. T2ρ measured in phantoms and human subjects were used during simulation.

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