Abstract #5002

Reducing fluctuations in prostate DCE-MRI physiological parameters using muscle as a reference to modulate arterial input function

Xiaobing Fan¹, Aritrick Chatterjee¹, Grace H. Lee¹, Ambereen Yousuf¹, Tatjana Antic², Aytekin Oto¹, and Gregory S. Karczmar¹

¹Radiology, University of Chicago, Chicago, IL, United States, ²Pathology, University of Chicago, Chicago, IL, United States

Synopsis

We introduce a method to modulate arterial input functions (AIFs) using gluteal muscle as reference. The method was tested on a split injection protocol for prostate dynamic contrast enhanced (DCE) MRI: first injecting 30% of the standard dose (30PSD), after two minutes, followed by 70% of the standard dose (70PSD) of gadoterate meglumine. The AIFs were measured from the iliac artery for both doses and used to analyze 70PSD data. By assuming gluteal muscle K^trans=0.1min^-1 and v_e=0.1 to modulate AIFs for both doses, the fluctuations of calculated physiological parameters were significantly reduced when compared to using the original AIFs.

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