Abstract #5002

Reducing fluctuations in prostate DCE-MRI physiological parameters using muscle as a reference to modulate arterial input function

Xiaobing Fan¹, Aritrick Chatterjee¹, Grace H. Lee¹, Ambereen Yousuf¹, Tatjana Antic², Aytekin Oto¹, and Gregory S. Karczmar¹

¹Radiology, University of Chicago, Chicago, IL, United States, ²Pathology, University of Chicago, Chicago, IL, United States

Synopsis

We introduce a method to modulate arterial input functions (AIFs) using gluteal muscle as reference. The method was tested on a split injection protocol for prostate dynamic contrast enhanced (DCE) MRI: first injecting 30% of the standard dose (30PSD), after two minutes, followed by 70% of the standard dose (70PSD) of gadoterate meglumine. The AIFs were measured from the iliac artery for both doses and used to analyze 70PSD data. By assuming gluteal muscle K^trans=0.1min^-1 and v_e=0.1 to modulate AIFs for both doses, the fluctuations of calculated physiological parameters were significantly reduced when compared to using the original AIFs.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.