Abstract #5001

High Resolution 3D Ultra-Short Echo Time MRI with Rosette k-Space Pattern for Brain Iron Content Mapping

Xin Shen¹, Ali Caglar Özen², Humberto Monsivais³, Serhat Ilbey², Antonia Sunjar¹, Aparna Karnik⁴, Mark Chiew⁵, and Uzay Emir^1,3

¹Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ²Department of Radiology, Medical Physics, University of Freiburg, Freiburg, Germany, ³Health Science Department, Purdue University, West Lafayette, IN, United States, ⁴Elmore Family School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States, ⁵Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom

Synopsis

This study aimed to detect brain iron content with a novel high resolution (0.94 mm isotropic voxel) ultra-short echo time (UTE) MRI based on rosette k-space trajectory. Non-invasive monitoring of brain iron content is beneficial, because the iron concentration increases during normal brain development, but is associated with many neurodegenerative diseases. With the ultra-short echo time (TE=20μs), the fast signal decay caused by high iron concentration can be captured. The relationship between iron concentration and signal intensity was quantified based on phantom study, and was used for modulation of the in vivo data to produce images of iron-rich brain regions.

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