Abstract #5027

Spatial encoding with a 48-ch Transcranial Magnetic Stimulation coil array: Application to diffusion imaging

Jason Peter Stockmann^1,2, Lucia Navarro de Lara¹, Mohammed Daneshzand¹, Qinglei Meng¹, Congyu Liao³, Hong-Hsi Lee^1,2, Lawrence L Wald^1,2, Berkin Bilgic^1,2, Susie Huang^1,2, and Aapo Nummenmaa^1,2

¹A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Lucas Center, Stanford University, Stanford, CA, United States

Synopsis

We show that multi-channel TMS (mTMS) probe arrays can be used to generate B-fields inside the head for spatial encoding in concurrent TMS/MRI studies. We assess the field-synthesis capability of a 48-ch mTMS array for diffusion imaging and spatial encoding more broadly. Proof-of-concept diffusion imaging experiments on a 3T scanner using a 3-axis TMS probe achieve spatially-varying b-values >500 s/mm² at the depth of the peripheral gray matter using only 4A of current. We consider the potential for scaling up to 200A for studies of gray matter microstructure.

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