Abstract #5033
Combined Stiffness and PDFF Phantom for Quality Assurance of Quantitative Magnetic Resonance Elastography and Fat Fraction Imaging
David Rutkowski1, Alejandro Roldán-Alzate2,3,4, José Guerrero-González1, Diego Hernando1,3,5, Scott B Reeder1,3,4,5,6,7, and Jean H Brittain1
1Calimetrix, Madison, WI, United States, 2Mechanical Engineering, University of Wisconsin, Madison, WI, United States, 3Radiology, University of Wisconsin, Madison, WI, United States, 4Biomedical Engineering, University of Wisconsin, Madison, WI, United States, 5Medical Physics, University of Wisconsin, Madison, WI, United States, 6Medicine, University of Wisconsin, Madison, WI, United States, 7Emergency Medicine, University of Wisconsin, Madison, WI, United States
Synopsis
MRI proton density fat fraction (PDFF) and MR elastography (MRE) methods are frequently used to evaluate patients with known or suspected NAFLD or NASH. Reference standards (phantoms) are needed for quality assurance of these methods. Currently available phantoms mimic only a single tissue property. A phantom that simultaneously mimics PDFF and tissue stiffness would more realistically mimic NAFLD/NASH tissue and would enable robust and convenient quality assurance. In this work, a chemical formulation and phantom configuration were developed for a multi-layer combined PDFF-MRE phantom, in which each layer simultaneously mimics different PDFF and stiffness values.
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