R2* correction is necessary for improving the accuracy of fat fraction quantification in assessing steatosis. However, the dephasing effects of concurrent iron overload may be dependent on the size of iron and fat particles. In this study, we controlled the size of fat droplets in fat-iron emulsion phantoms by traditional stir bar methods and homogenization. R2* and far fraction (FF) values were estimated with multi-spectral models that assume a common or independent R2* for water and fat. Our results show that R2* was slightly reduced in homogenized phantoms at higher fat fractions compared to stir bar phantoms.
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