Abstract #5038

Validation of motion-robust, blood-suppressed, reduced-distortion liver diffusion techniques in a pulsatile motion phantom

Ruiqi Geng^1,2, James Rice^1,3, Yuxin Zhang^1,2, David R. Rutkowski^1,3, Alejandro Roldán-Alzate^1,3, Arnaud Guidon⁴, and Diego Hernando^1,2,5,6

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁴GE Healthcare, Boston, MA, United States, ⁵Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁶Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Conventional liver diffusion MRI acquisitions suffer from several challenges including pulsatile motion-induced signal voids and B0-induced distortions. In this study, we validated motion-robust, blood-suppressed, reduced-distortion liver diffusion techniques in an anatomically accurate liver phantom including controlled pulsatile motion. By combining optimized motion-compensated, blood-suppressed diffusion waveforms (i.e. MODI) with msEPI acquisitions, superior image quality and quantitative performance can be achieved in the presence of various degrees of compressive tissue motion.

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