(ISMRM 2024) Integrated MRI radiomics, tumor microenvironment, and clinical risk factors improving survival prediction in patients with glioblastoma
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Abstract #0021

Integrated MRI radiomics, tumor microenvironment, and clinical risk factors improving survival prediction in patients with glioblastoma

Qing Zhou1 and Junlin Zhou1
1Lanzhou University Second Hospital, Lanzhou, China

Synopsis

Keywords: Tumors (Post-Treatment), Neuro

Motivation: The patients with glioblastoma (Gb) with poor prognosis and quality of life.

Goal(s): To construct a comprehensive model for predicting the prognosis of patients with Gb using a radiomics method and integrating tumor microenvironment .

Approach: In total, 149 patients with isocitrate dehydrogenase wild-type Gb were enrolled retrospectively. Selected the best feature combination related to Gb overall survival. Clinical-radiomics-TME models were established.

Results: Lasso-Cox analyses were used to screen the factors related to OS in patients with Gb, including age, peritumoral edema, tumor purity, tumor-associated macrophages, and the 21 radiomics features. The clinical-radiomics-TME model had the best survival prediction ability, the C-indices was 0.727.

Impact: Considering the poor prognosis of IDH wild-type Gb, we explored additional prognostic risk factors and established a survival prediction model. The clinical-radiomics-TME comprehensive model showed a significant improvement compared to other models and was most effective in predicting patient survival.

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Keywords

clinical