Abstract #0030

Relaxation-exchange imaging (REXI) for the measurement of trans-barrier water exchange in choroid plexus

Xuetao Wu^1,2, Zejun Wang³, Yu Yin⁴, Qingping He⁵, Yi-Cheng Hsu⁶, Rong Xue^1,2, and Ruiliang Bai⁷

¹State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ²University of Chinese Academy of Sciences, Beijing, China, ³Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ⁴Department of Chemistry, Zhejiang University, Hangzhou, China, ⁵School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China, ⁶MR Collaboration, Siemens Healthcare, Shanghai, China, ⁷Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, China

Synopsis

Keywords: Neurofluids, Neurofluids, choroid plexus, Blood-CSF barrier, relaxation exchange

Motivation: Scarcity of non-invasive imaging techniques of choroid plexus function hindered our knowledge of the blood-cerebrospinal fluid barrier (BCSFB).

Goal(s): We aimed to measure the trans-barrier water exchange rate in choroid plexus.

Approach: We developed a new imaging method and contrast mechanism, named relaxation-exchange imaging (REXI), and validated its feasibility on both phantoms and rats.

Results: REXI successfully captured the changes in proton exchange rate of urea-water phantoms at varying pH. In-vivo experiments on rats showed the potential of REXI to measure the trans-barrier water exchange in choroid plexus.

Impact: Given the emerging importance of neurofluids and choroid plexus, our novel MRI method REXI provides a way to measure the trans-barrier water exchange in CP and a potential imaging tool to evaluate CP function in future studies.

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