Abstract #0031

Choroid plexus atrophy in premanifest synucleinopathy using 7 Tesla MRI: an underlooked mechanism for α-synuclein accumulation?

Firdaus Fabrice Hannanu¹, Stephan Grimaldi^1,2, Kavita Singh^1,3, Subhranil Koley¹, Ambra Stefani^1,4, Aleksandar Videnovic^5,6, Guadalupe Garcia-Gomar^1,7, and Marta Bianciardi^1,6

¹Brainstem Imaging Laboratory, Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²Department of Neurology and Movement Disorders, APHM, Hôpital Universitaire Timone, Marseilles, France, ³Multiscale Imaging and Integrative Biophysics Unit, LBN, National Institute on Aging, NIH, Baltimore, MD, United States, ⁴Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria, ⁵Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ⁶Division of Sleep Medicine, Harvard University, Boston, MA, United States, ⁷Escuela Nacional de Estudios Superiores Unidad Juriquilla, Universidad Nacional Autónoma de México, Querétaro, Mexico

Synopsis

Keywords: Parkinson's Disease, High-Field MRI, Choroid Plexus, Synucleinopathy, RBD

Motivation: As opposed to Alzheimer's disease, the mechanism linking neurotoxic protein accumulation to alterations in neurofluid turnover and in neuroimmunity due to choroid plexus (ChP) changes is understudied in premanifest synucleinopathy.

Goal(s): To determine changes in the structure of ChP in premanifest synucleinopathy and to generate a ChP probabilistic atlas.

Approach: ChP in multi-contrast 7 Tesla images of 12 premanifest synucleinopathy and 12 sex-and-age-matched controls were evaluated in terms of volume and signal intensity.

Results: Reduced ChP volume in premanifest synucleinopathy suggested ChP atrophy that may result in neurofluid dynamics and neuroimmune function impairment; a probabilistic atlas of ChP was generated.

Impact: ChP atrophy observed in premanifest synucleinopathy using high-resolution multi-contrast 7-Tesla MRI suggests a potential role of ChP in pathophysiology of synucleinopathies, urging further investigation. Probabilistic ChP atlas may aid precise MRI localization in future studies of ChP in living humans.

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