Abstract #0033

MRI study of enlarged choroid plexus in patients with spinocerebellar ataxia type 3.

Zhiming Zhen^1,2, Yonghua Huang¹, Chenghao Cao¹, Yanqiu Hua¹, Peiling Ou¹, Wei Chen³, Wei Chen¹, Zhentao Zuo⁴, and Chen Liu^1,2

¹Department of Radiology, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China., Chongqing, China, ²7T Magnetic Resonance Imaging Translational Medical Center, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China., Chongqing, China, ³MR Research Collaboration Team, Siemens Healthineers Ltd., Wuhan 430000, China, Wuhan, China, ⁴State Key Laboratory of Brain and Cognitive Science, Beijing MR Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100000, China, Beijing, China

Synopsis

Keywords: Other Neurodegeneration, Brain, spinocerebellar ataxia type 3

Motivation: The role of cerebral immune and homeostatic structures of choroid plexus (CP) in SCA3 patients remains elusive.

Goal(s): The objective of this study is to investigate the volumetric changes in the choroid plexus.

Approach: Whole brain of SCA3 patients was imaged using a 3T MRI scanner and the volume of CP was analyzed.

Results: The findings revealed that CP volume was significantly larger in the SCA3 group compared to normal control group, exhibiting a positive correlation with both the number of ATXN3 repeats and scores of motor function abnormalities.

Impact: The abnormal change of CP volume may serve as a new marker for distinguishing SCA3 patients

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