Keywords: Biology, Models, Methods, Metabolism, Chemogenetics, fMRS
Motivation: To complement previous fMRI studies of interhemispheric pathways, we propose to characterize the interhemispheric metabolism using functional magnetic resonance spectroscopy (1H-fMRS).
Goal(s): To demonstrate the feasibility of chemogenetic 1H-fMRS in the rat brain at 7T.
Approach: DREADDs and Sham viruses were injected in the right motor cortex of rat. Neural activation was induced by a 1mg/kg IP bolus of Clozapine-N Oxide (CNO). Spectra were acquired continuously prior and following CNO injection and quantified with a temporal resolution of 5 minutes.
Results: Relative concentration changes were found for myo-Inositol, Taurine, Glutamate and NAA in the motor cortex of chemo-induced rats following CNO injection.
Impact: Functional metabolic findings will greatly complement our knowledge of interhemispheric pathway allowing a better understanding of long-distance circuits known to initiate both excitation and inhibition.
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