Abstract #0053

Magnetic Resonance Elastography captures tumor invasiveness and therapy response in the invasive S24-glioma model

Hannah Elisabeth Fels-Palesandro^1,2, Sophie Heuer^3,4, Berin Boztepe^1,5, Yannik Streibel¹, Chenchen Pan^3,4, Ina Maria Weidenfeld^1,2, Manuel Fischer¹, Volker Sturm¹, Daniel Dominguez-Azorin^3,4, Ralph Sinkus^6,7, Amir Abdollahi^2,8, Sabine Heiland¹, Frank Winkler^3,4, Martin Bendszus¹, Michael Breckwoldt^1,5, and Katharina Schregel^1,4

¹Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, ²Clinical Cooperation Unit Translational Radiation Oncology, Deutsches Krebsforschungszentrum, Heidelberg, Germany, ³Neurology, Heidelberg University Hospital, Heidelberg, Germany, ⁴Clinical Cooperation Unit Neurooncology, Deutsches Krebsforschungszentrum, Heidelberg, Germany, ⁵Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, Deutsches Krebsforschungszentrum, Heidelberg, Germany, ⁶School of Biomechanical Engineering and Imaging Science, King's College London, London, United Kingdom, ⁷INSERM UMRS1148 - Laboratory for Vascular Translational Science, University of Paris, Paris, France, ⁸Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany

Synopsis

Keywords: Elastography, Elastography, Cancer, Neuro

Motivation: In a neurooncological setting clinically established MRI-sequences have shortcomings with regards to tumor invasion and therapy-associated parenchyma changes.

Goal(s): Our goal was to determine if MRE and the ADC could improve detection of tumor cell invasion and radiotherapy effects.

Approach: 23 tumor-bearing mice and 9 sham injected mice underwent MRE- and MRI-scans for up to 16 weeks, a subgroup of animals underwent additional radiotherapy.

Results: MRE was sensitive to early tumor invasion and MRE and ADC captured radiotherapy effects so far not detectable with established MRI-sequences.

Impact: In a preclinical setting the ADC and especially MRE allow for a better characterization of therapeutic effects and tumor cell invasion and should thus also be evaluated in a clinical setting.

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