Keywords: Lung, Lung, Pulmonary Hypertension
Motivation: Pulmonary hypertension (PH) and reduced capillary blood volume, VC’, have competing effects on oscillations of the hyperpolarized 129Xe red blood cell (RBC) resonance, rendering it difficult to distinguish PH.
Goal(s): Our goal was to correct RBC oscillations for reduced VC', then use corrected oscillations to estimate pulmonary vascular resistance (PVR).
Approach: We developed a model of RBC oscillations as a function of VC’ in a cohort without known PH and used this model to derive a correction factor. Corrected oscillations were regressed against known PVR in a cohort with suspected PH.
Results: Corrected oscillations improved PH sensitivity and were significantly correlated to PVR.
Impact: Correcting oscillations in the hyperpolarized 129Xe red blood cell resonance for reduced pulmonary capillary blood volume improves sensitivity to pulmonary hypertension and permits estimation of pulmonary vascular resistance, thereby offering a non-invasive diagnostic alternative to right heart catheterization.
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