Abstract #0090

Venous Return in Chronic Obstructive Pulmonary Disease Assessed with 4D Flow MRI

Timothy W Houston¹, David Dushfunian ², Michael Markl², Oliver Wieben¹, Martin R. Prince³, Wei Shen³, James Carr², David A. Bluemke¹, Michael Backman³, Sachin Jambawalikar³, Bharath Ambale Venkatesh⁴, Joao Lima⁴, Prachi Agarwal⁵, John Paul Finn⁶, Christopher B. Cooper⁶, Jing Liu⁷, Yoo Jin Lee⁷, Joyce Schroeder⁸, Dalane W. Kitzman⁹, and Graham Barr³

¹University of Wisconsin-Madison, Madison, WI, United States, ²Northwestern University Feinberg School of Medicine, Chicago, IL, United States, ³Columbia University, New York, NY, United States, ⁴Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵University of Michigan School of Medicine, Ann Arbor, MI, United States, ⁶University of California Los Angeles, Los Angeles, CA, United States, ⁷University of California San Francisco, San Francisco, CA, United States, ⁸University of Utah School of Medicine, Salt Lake City, UT, United States, ⁹Wake Forest University, Winston-Salem, NC, United States

Synopsis

Keywords: Heart Failure, Blood vessels, COPD, Hemodynamics, Heart Failure, 4D Flow

Motivation: Chronic obstructive pulmonary disease (COPD) and emphysema are associated with hemodynamic changes in the pulmonary vasculature, possibly related to increased intra-thoracic pressure during expiration, altering venous return into the thorax.

Goal(s): Assess the association of respiratory dysfunction with hemodynamic parameters of venous return.

Approach: Velocity, kinetic energy, and stasis in the superior vena cava and inferior vena cava were quantified with 4D Flow MRI in 72 subjects across the COPD spectrum in an ongoing study (SPIROMICS HF).

Results: Our results show an association of impaired (reduced) venous return to the thorax with airway obstruction as assessed by spirometry.

Impact: This study demonstrates impaired venous return in subjects with COPD, which warrant further investigations into the cardiopulmonary interactions of right heart flow in COPD and its potential value as a noninvasive marker of disease progression.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.