Keywords: Flow, Velocity & Flow, Aorta, Pulse wave velocity, Arterial stiffness
Motivation: To measure 3D pulse wave velocity (PWV) for the investigation of arterial stiffness on a local scale which could benefit patients with aortic disease.
Goal(s): To calculate aortic 3D PWV with the flow-area method and compare with the global method.
Approach: The flow-area method for PWV calculation is applied to 4D flow data combined with automatically-segmented 4D balanced SSFP scans along the thoracic aorta.
Results: This measurement is feasible and shows the expected trend of increasing PWV along the length of the aorta. Averaged values corresponded moderately with the global method.
Impact: Increased arterial stiffness measured by PWV is a well-established risk factor for adverse cardiac events. Development of novel MRI technology to locally map arterial stiffness may allow for improved risk-stratification in cardiovascular disease and ultimately guide therapy.
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