Abstract #0101
Chronic Obstructive Pulmonary Disease is Associated with Impaired Cardiac Hemodynamics: A SPIROMICS HF Study
David Dushfunian1, Timothy W. Houston2, Michael Markl1, Oliver Wieben2, Martin R. Prince3, Wei Shen4, James Carr1, David Bluemke5, Michael Backman6, Sachin R. Jambawalikar3, Bharath Ambale Venkatesh7, Joao Lima7, Prachi Agarwal8, Steven Lloyd9, Paul Finn10, Christopher B. Cooper11, Jing Liu12, Yoo Jin Lee12, Joyce Schroeder13, Dalane W. Kitzman14, and R. Graham Barr15
1Department of Radiology, Northwestern University, Chicago, IL, United States, 2Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 3Department of Radiology, Columbia University Medical Center, New York, NY, United States, 4Department of Pediatrics, Columbia University Medical Center, New York, NY, United States, 5Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, 6Columbia University Medical Center, New York, NY, United States, 7Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 8Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI, United States, 9University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, United States, 10Department of Radiology, University of California Los Angeles, Los Angeles, CA, United States, 11Departments of Medicine and Physiology, University of California Los Angeles, Los Angeles, CA, United States, 12Department of Radiology, University of California San Francisco, San Francisco, CA, United States, 13Department of Radiology, University of Utah School of Medicine, Salt Lake City, UT, United States, 14Department of Cardiology, Wake Forest University, Winston-Salem, NC, United States, 15Department of Medicine, Columbia University Medical Center, New York, NY, United States
Synopsis
Keywords: Flow, Velocity & Flow, COPD, Lung, hemodynamics
Motivation: Previous studies have suggested impaired cardiovascular function in patients with chronic obstructive pulmonary disease (COPD). However, the association between lung disease severity and the degree of cardiac hemodynamic impairment is not well understood.
Goal(s): We aimed to characterize the hemodynamic changes seen in COPD in order to gain insight into the mechanisms relating COPD and heart failure.
Approach: We analyzed 4D-flow derived hemodynamics in a preliminary sample of 72 participants from the SPIROMICS-HF study.
Results: We found that impaired hemodynamics in the right atrium (blood flow kinetic energy and velocity) and pulmonary artery (flow stasis and velocity) are associated with greater COPD severity.
Impact: This study represents a key step in exploring the cardiopulmonary hemodynamic interaction in chronic obstructive pulmonary disease.
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