Abstract #0105

Association of Dynamic Contrast Enhanced (DCE) MRI of Abdominal Aortic Aneurysm (AAA) Wall with Progression: A Prospective Study

Ang Zhou¹, Huiming Dong², Joseph Leach¹, Jonas Schollenberger¹, Chengcheng Zhu³, Yoo Jin Lee¹, James Iannuzzi⁴, Warren Gasper⁴, David Saloner¹, and Dimitrios Mitsouras¹

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Department of Radiation Oncology, University of California Los Angeles, Los Angeles, CA, United States, ³Department of Radiology, University of Washington, Seattle, WA, United States, ⁴Department of Surgery, University of California San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Vascular, Cardiovascular

Motivation: Abdominal Aortic Aneurysms (AAAs) are common, and rupture has >80% mortality. The standard of care is regular surveillance and repair when maximum diameter thresholds are reached. Many ruptures occur before AAA reach these thresholds at surveillance.

Goal(s): The goal of this prospective study was to determine if AAA wall contrast kinetics using DCE MRI, presumably associated with inflammatory microvasculature, independently predict progression.

Approach: 23 AAA patients were followed over a mean follow-up interval of 14±6 months.

Results: K^trans was significantly associated with progression after controlling for AAA maximum diameter. This suggests that DCE MRI may provide useful information regarding future AAA progression.

Impact: Contrast kinetics in AAA wall tissue assessed by DCE MRI may be useful for improving AAA risk stratification.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.