Abstract #0107

ODF-Fingerprinting reconstruction of corticospinal tracts for preoperative planning of brain tumor resection

Patryk Filipiak^1,2, Kamri Clarke^1,2, Timothy M. Shepherd^1,2, Saad I. Gondal^1,2,3, Mary Bruno^1,2, Dimitris G. Placantonakis⁴, and Steven H. Baete^1,2,5

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Herricks High School, New Hyde Park, NY, United States, ⁴Department of Neurosurgery, Perlmutter Cancer Center, Neuroscience Institute, Kimmel Center for Stem Cell Biology, NYU Langone Health, New York, NY, United States, ⁵Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Tractography, Tractography & Fibre Modelling, preoperative planning, ODF-fingerprinting, pyramidal tract, corticospinal tract, brain tumor, BOLD activation, task fMRI

Motivation: Tractography enables preoperative visualization of major neural pathways altered or displaced by a brain tumor; however, it often fails to reconstruct the cortical terminations of corticospinal tracts due to the complex bending and branching formations of fibers.

Goal(s): We aim to improve tracking of corticospinal tracts in their most challenging regions of hand and face projections to the motor cortex.

Approach: We refine reconstruction of fibers inside corticospinal tracts by incorporating ODF-Fingerprinting into the tracking pipeline.

Results: With ODF-Fingerprinting, we increased the overlap between the reconstructed corticospinal tracts and the cortical regions activated during task-based functional MRI involving hand and face movement.

Impact: Our improved reconstruction can help decrease the incidence of postoperative deficits by identifying the structural neural connections that need to be spared during tumor resection.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.