Abstract #0108

White matter neurite alterations in dementia with Lewy body bodies: influence of amyloid-β and tau

Elijah Mak^1,2, Robert Reid¹, Scott Przybelski³, Timothy Lesnick³, Christopher Schwarz¹, Matthew Senjem¹, Sheelakumari Raghavan ¹, Prashanthi Vemuri¹, Clifford R Jack ¹, Hoon K Min¹, Manoj K Jain⁴, Toji Miyagawa⁵, Leah K Forsberg⁵, Julie Fields⁶, Rodolfo Savica⁵, Jonathan Graff-Radford⁵, David T Jones ⁵, Hugo Botha ⁵, Erik K St. Louis^5,6, David S Knopman⁵, Vijay Ramanan⁵, Dennis Dickson⁷, Neill R Graff-Radford⁸, Tanis J Ferman⁹, Ronald C Petersen⁵, Val J Lowe¹, Bradley F Boeve ⁵, John T O'Brien², and Kejal Kantarci¹

¹Department of Radiology, Mayo Clinic, Rochester, MN, United States, ²Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, ³Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States, ⁴Department of Radiology, Mayo Clinic, Jacksonville, FL, United States, ⁵Department of Neurology, Mayo Clinic, Rochester, MN, United States, ⁶Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States, ⁷Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, United States, ⁸Laboratory of Medicine and Pathology, Mayo Clinic, Jacksonville, FL, United States, ⁹Department of Neurology, Mayo Clinic, Jacksonville, FL, United States

Synopsis

Keywords: Microstructure, Dementia, Lewy bodies, NODDI, DTI, Amyloid, Tau

Motivation: The influence of Alzheimer’s disease (AD) copathologies on white matter neurite changes in dementia with Lewy bodies (DLB) remains unclear.

Goal(s): To delineate the severity of neurite abnormalities and their associations with amyloid and tau PET imaging in DLB.

Approach: We compared Neurite Orientation Dispersion and Density Imaging metrics in the DLB spectrum (DLBs, n=45) against controls (n=45), and evaluated their correlations with amyloid-β ([11C]-PiB) and tau ([18F]-Flortaucipir) PET.

Results: The DLBs exhibited widespread white matter injury relative to controls. Elevated tau deposition, but not amyloid-β burden, was significantly associated with neurite abnormalities, predominantly involving the temporal and limbic white matter tracts.

Impact: These findings demonstrate the impact of AD copathologies on widespread neurite abnormalities in people with DLB, underscoring the importance of further elucidating the mechanisms underlying amyloid-β and tau deposition, and evaluating anti-AD disease-modifying interventions for DLB.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.