Keywords: DWI/DTI/DKI, Diffusion/other diffusion imaging techniques, Tract-Based Spatial Statistics;neurodevelopmental disorder;children
Motivation: The diagnosis of global developmental delay (GDD) heavily relies on clinical scale assessments, which are highly subjective and present challenges for early diagnosis and intervention.
Goal(s): The purpose of this study was to investigate the changes in white matter microstructure in children with GDD.
Approach: We used a diffusional kurtosis imaging (DKI)-based TBSS approach to analyze the whole brain.
Results: Our findings indicate abnormalities in multiple white matter brain regions among children with GDD. Additionally, DKI parameters were found to be correlated with clinical developmental levels.
Impact: The DKI can offer quantitative parameter values for assessing microstructural changes in the brain of GDD, making it a promising diagnostic tool.
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