Abstract #0126

Multiple advanced diffusion models for preoperative prediction of macrotrabecular-massive subtype in solitary hepatocellular carcinoma

Yongjian Zhu¹, Wei Cai¹, Yueluan Jiang², Yinqiao Yi³, Guang Yang³, and Xinming Zhao¹

¹Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ²MR Research Collaboration, Siemens Healthineers, Beijing, China, ³Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China

Synopsis

Keywords: Microstructure, Diffusion/other diffusion imaging techniques, Tumor

Motivation: Pretherapeutic characterization of the aggressive macrotrabecular-massive (MTM) subtype hepatocellular carcinoma (HCC) may promote the implementation of precision treatment and improvement of prognosis.

Goal(s): To investigate the value of multiple advanced diffusion models in identifying the MTM subtype of HCC preoperatively.

Approach: DWI of twelve b-values (0-2000 s/mm²) were performed in 70 patients with HCC. Multiple diffusion-derived parameters were extracted and compared between MTM and non-MTM HCC. The predictive efficacy of various diffusion parameters was assessed.

Results: CTRW_α exhibited the highest predictive performance with an AUC of 0.861 among individual parameters, a combination of parameters could improve the AUC to 0.912.

Impact: MTM is a distinct subtype of HCC and is associated with aggressive biological behavior, but it might be a suitable candidate for immunotherapy. Our result demonstrated that non-Gaussian diffusion parameters could serve as promising biomarkers for predicting MTM preoperatively.

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