Keywords: Task/Intervention Based fMRI, fMRI (task based), DIANA
Motivation: Toi et al. reported a revolutionary approach of direct imaging of neuronal activity (DIANA) by fMRI in anesthetized mice at 9.4 T. However, anesthesia has a profound impact on the central nervous system, leading to modifications in physiological parameters.
Goal(s): Our goal is to investigate Direct Neuronal Activity-related (DIANA) fMRI in awake mice.
Approach: We performed the event-related cerebral functional magnetic resonance imaging and DIANA experiment in habit-trained awake mice.
Results: In response to the electrical stimulation, a statistically significant increase in the DIANA signal was observed in the contralateral S1FL compared with the prestimulus signal (p < 0.005, n = 6 mice).
Impact: Direct detection of neural activity allows us to better understand the rapid dynamics of neural activity, which will help improve the understanding and diagnosis of neurological diseases.
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