Keywords: Aging, Aging, parcellation
Motivation: The human brain undergoes a remarkable development from newborn to adulthood in cortex, white matter, and connectivity in previous studies. We speculated connectivity-based cortical parcellation may also change during this process.
Goal(s): To explore whether and how connectivity-based parcellations of different cortices changed from neonate to adult.
Approach: We utilized diffusion MRI (dMRI) to investigate the structure connectivity-based parcellations of cortical sub-regions and compared the parcellation-related features among infants, toddlers, and adults.
Results: We observed significantly altered parcellation profiles and changing connectivity patterns during developed. Especially, we found larger alternations in high-order cortex, such as insula, compared to primary sensory and motor cortices.
Impact: Connectivity-based parcellation provided a new insight to assess the development of human brain. Primary cortex has developed sufficiently in early life while high-order cortex developed significantly from newborn to adult. Future studies will fill the gap from toddler to adult.
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