Abstract #0136

Structural connectome shapes the maturation of cortical morphology from childhood to adolescence

Xinyuan Liang¹, Lianglong Sun¹, Xuhong Liao², Tianyuan Lei¹, Mingrui Xia¹, Dingna Duan¹, Zilong Zeng¹, Qiongling Li¹, Zhilei Xu¹, Weiwei Men³, Yanpei Wang¹, Shuping Tan⁴, Jia-Hong Gao³, Shaozheng Qin¹, Sha Tao¹, Qi Dong¹, Tengda Zhao¹, and Yong He¹

¹State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China, ²School of Systems Science, Beijing Normal University, Beijing, China, ³Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China, ⁴Beijing Huilongguan Hospital, Beijing, China

Synopsis

Keywords: Structural Connectivity, Brain Connectivity, Adolescents

Motivation: Cortical thinning is an important hallmark of the maturation of brain morphology during childhood and adolescence. However, the connectome-based wiring mechanism that underlies cortical maturation remains unclear.

Goal(s): We aim to model how the maturational pattern of cortical morphology is shaped by white matter connectome architecture.

Approach: We integrated neuroimaging, connectome, transcriptome analyses and computational modeling.

Results: We found that the maturational patterns of cortical morphology are constrained by the white matter connectome and are particularly represented using a network-based diffusion model. Such constraints are predominantly located in frontoparietal nodes and are linked with the expression of genes associated with microstructural developmental processes.

Impact: Our results highlight the importance of white matter network structure in shaping the coordinated maturation of regional cortical morphology, which demonstrates the feasibility of using a network model to reveal the maturational principle of cortical morphology from childhood to adolescence.

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