Abstract #0137

Choroid Plexus Structural and vascular Changes Associated with Aging in the HCP Dataset

Zhe Sun^1,2,3, Chenyang Li^1,2,3, Thomas Wisniewski^4,5, and Yulin Ge^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, NYU Grossman School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, NYU Grossman School of Medicine, New York, NY, United States, ³Vilcek Institute of Graduate Biomedical Sciences, NYU Grossman School of Medicine, New York, NY, United States, ⁴Center for Cognitive Neurology, NYU Grossman School of Medicine, New York, NY, United States, ⁵Departments of Pathology and Psychiatry, NYU Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Aging, Aging, Human Connectome Project, choroid plexus

Motivation: Analyzing ChP changes in normal aging is essential for grasping its role in neurological disorders.

Goal(s): To evaluate ChP changes with age using diffusion and perfusion MRI in a lifespan HCP-aging dataset.

Approach: MR images of 641 healthy participants aged from 36 to 90 years old were analyzed to extract diffusion and perfusion measurements of ChP to investigate their age-related changes.

Results: With age, the ChP undergoes significant changes, including increased volume, reduced blood flow, elevated MD values, and a more rapid decline in blood flow compared to gray and white matter.

Impact: This study offers a comprehensive evaluation of age-related changes in the ChP, enhancing our comprehension of its potential involvement in age-related cognitive decline. Furthermore, age-related ChP alterations exhibit distinct patterns compared to changes in gray and white matter.

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