Abstract #0138

Age-related differences in macromolecular resonances observed in ultra-short-TE STEAM MR spectra at 7 T

Guglielmo Genovese¹, Melissa Terpstra¹, Pavel Filip^1,2, Silvia Mangia¹, J. Riley McCarten^3,4, Laura S. Hemmy^3,5, and Małgorzata Marjańska¹

¹Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ²Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic, ³Geriatric Research, Education and Clinical Center, Veterans Affairs Health Care System, Minneapolis, MN, United States, ⁴Department of Neurology, University of Minnesota, Minneapolis, MN, United States, ⁵Department of Psychiatry, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: Spectroscopy, Data Analysis, Macromolecules, LCModel, ultra-high field

Motivation: Macromolecular signals mainly originate from amino-acids within flexible cytosolic proteins, contributing to ¹H-MR spectra. Previous studies have yielded inconsistent results regarding age-related differences in macromolecular resonances.

Goal(s): To investigate the macromolecular content across a wide age range in a large cohort of healthy participants.

Approach: Spectroscopy data were acquired at 7 T. The macromolecular content was investigated in 134 datasets from a cohort ranging in age from 19 to 89 years.

Results: Age-related effects were observed for macromolecular peaks. Some macromolecular resonances had significantly higher content at 30-40 years of age while others at 60-70 years of age.

Impact: Our findings strengthen the necessity of using age-matched measured macromolecules during quantification of metabolite concentrations. The ability to detect differences in macromolecular content may be helpful for understanding the neurodegenerative processes associated with aging.

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