Abstract #0141

Submillimeter Isotropic in vivo Quantitative Susceptibility Mapping: Application to Women with Suspected Coronary Microvascular Dysfunction

Arzu C Has Silemek^1,2, Sreekanth Madhusoodhanan¹, Janet Wei ³, Oana Dumitrascu⁴, Sarah Kremen¹, Debiao Li², Michael D Nelson⁵, Zaldy S Tan⁶, Jeffrey Wertheimer⁷, Yibin Xie², Noel Bairey Merz³, Wei Gao², and Pascal Sati¹

¹Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Department of Biomedical Sciences and Imaging, Biomedical Imaging Research Institute (BIRI), Cedars-Sinai Medical Center, Los Angeles, CA, United States, ³Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Department of Neurology, Mayo Clinic College of Medicine and Science, Scottsdale, AZ, United States, ⁵Department of Kinesiology, The University of Texas at Arlington, Arlington, TX, United States, ⁶Departments of Neurology and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁷Department of Physical Medicine and Rehabilitation, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Synopsis

Keywords: Aging, Quantitative Susceptibility mapping, Heart, Brain, women, INOCA, Aging, Dementia

Motivation: The study's motivation lies in overcoming the low-resolution limitations of Quantitative susceptibility mapping (QSM) in 3T-MRI, which is critical for investigating brain aging and neurodegeneration.

Goal(s): We aimed to construct high-resolution QSM using submillimeter T2*-3D-EPI sequence to measure iron deposition in the cortical and deep gray matter of women with suspected coronary microvascular dysfunction.

Approach: The approach involved a novel imaging protocol, TGV-based QSM reconstruction, and statistical analysis correlating iron deposition with cardiovascular health markers.

Results: Results indicate a significant association between brain iron accumulation and microvascular heart conditions, pointing to a potential interconnected pathology in women with suspected coronary microvascular dysfunction.

Impact: The study's high-resolution QSM technique could revolutionize neuroimaging, allowing clinicians to detect microvascular changes early and personalize treatments. It opens avenues for exploring the systemic nature of microvascular diseases, potentially altering approaches to managing neurodegenerative and cardiovascular conditions.

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