Keywords: Quantitative Imaging, Kidney, tubule volume fraction, MRI, T2 mapping, multi-exponential analysis
Motivation: The increasing incidence of kidney diseases is a global concern and current biomarkers are inadequate. Changes in renal tubule volume fraction (TVF) may serve as a rapid biomarker for kidney disease and provide a better understanding of renal (patho-)physiology.
Goal(s): This study aims to measure TVF in in vivo rat kidney during acute tubular pressure increase.
Approach: This study uses the amplitude of the long T2-component as a surrogate for TVF in rats, by applying multiexponential analysis of the T2-driven signal decay.
Results: The results demonstrate that our approach is promising for research into quantitative assessment of renal TVF in in vivo applications.
Impact: This is the first report on in vivo assessment of relative changes in the renal TVF, which provides a potential rapid, noninvasive marker for kidney disease. This approach will be invaluable for gaining a better mechanistic understanding of renal (patho-)physiology.
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