Abstract #0162

Prolonged Central Thalamic Intermittent Theta-Burst Stimulation Rescued Memory Deficits in Alzheimer's Disease Mouse Model

Yi-Chen Lin¹, Ssu-Ju Li¹, Yu-Chun Lo², Yun-Ting Liu¹, Yi-Chun Lee³, Ting-Chieh Chen¹, Ching-Wen Chang¹, Yao-Wen Liang¹, Ching-Te Chen⁴, Sheng-Huang Lin^5,6, and You-Yin Chen^1,2

¹Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan, ²PhD Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, ³School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ⁴Abbott Neuromodulation, Austin, TX, United States, ⁵Department of Neurology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ⁶Department of Neurology, School of Medicine, Tzu Chi University, Hualien, Taiwan

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, Intermittent theta-burst stimulation (iTBS)

Motivation: Addressing the global AD crisis by investigating CT-iTBS as a non-pharmacological treatment to enhance memory and cognition.

Goal(s): To explore the therapeutic efficacy and determine the optimal treatment protocol of CT-iTBS in AD while unveiling its potential underlying mechanism for enhancing memory and cognitive functions.

Approach: Utilized brain magnetic resonance imaging analysis, behavioral tests, and immunofluorescence staining for assessing the therapeutic effect of different durations of CT-iTBS treatment.

Results: Prolonged CT-iTBS significantly enhanced cognitive and memory behaviors, altered brain functional connectivity, promoted a neuroprotective effect, and reduced amyloid accumulation in AD mouse model. These findings present a promising therapeutic avenue for AD patients.

Impact: Our findings revealed a highly promising avenue for enhancing the quality of life for individuals with AD and provided insights into the potential underlying neuroprotective mechanisms of CT-iTBS in alleviating memory deficits.

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