Keywords: Small Animals, Hyperpolarized MR (Gas), RILI, radiation, CSSR
Motivation: Chemical shift saturation recovery (CSSR) measurements are incredibly useful for quantifying pulmonary gas exchange and uptake; because CSSR is a spectroscopic technique, however, such measures are only global in nature.
Goal(s): Our goal was to develop an imaging-based technique for spatially-resolving CSSR measurements.
Approach: We demonstrated our technique’s utility in a rodent model of radiation-induced lung injury.
Results: Images of hyperpolarized-129Xe dissolved in the pulmonary membrane (Mem) and red blood cells (RBC) showed higher Mem signal and reduced RBC signal in radiated vs non-radiated lungs. Septal wall thickness (SWT) measurements derived on a quadrant level also revealed elevated SWT in the irradiated region.
Impact: We demonstrated a new imaging technique for regionally quantifying radiation-induced alterations in pulmonary gas exchange and uptake. This study lays the groundwork for future investigations aimed at improving radiotherapy strategies, mitigating radiotoxicity, and treating radiation-associated illness.
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