Keywords: Biology, Models, Methods, Cancer, BTK inhibition, mantle cell lymphoma models, early metabolic biomarker of response, 1H MRS with slice selective double frequency Hadamard Selective Multiple Quantum Coherence transfer pulse sequence, STEAM pulse sequence
Motivation: The current approaches to assess Bruton’s kinase inhibitor (BTK) therapeutic effects in cancer are not ideal.
Goal(s): Employing metabolic imaging, we evaluated the mode of action of ibrutinib (IBR), a BTK inhibitor, in mantle cell lymphoma (MCL) cells and xenografts.
Approach: Our approach using 1H MRS demonstrated that, in sensitive MCL models, IBR significantly impacted critical metabolic pathways, including glycolysis, glutaminolysis, and phospholipid metabolism, but had far less of an impact on IBR-poorly responsive cells.
Results: Changes in 1H MRS detectable lactate, alanine, and choline concentrations on various MCL models emerged as promising biomarkers of response or resistance to IBR.
Impact: Decreased intra-tumoral concentrations of lactate, alanine, and choline measured by 1H MRS during treatment can potentially become early and sensitive biomarkers of BTK inhibition in MCL and, likely, other lymphoma treatments.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords