Abstract #0175

Using Virtual Magnetic Resonance Elastography and IVIM to Evaluate Placental Microstructure and Microcirculation in Gestational Hypertension

Jing Deng¹, Yuwei Cao¹, Feifei Qu², Aining Zhang¹, Meng Zhao¹, Xin Zhou³, Xihu Mu¹, Yanglei Wu⁴, Jiacheng Song¹, Feiyun Wu¹, and Ting Chen¹

¹Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ²MR Research Collaboration, Siemens Healthineers, Shanghai, China, ³Department of Obstetrics & Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ⁴MR Research Collaboration, Siemens Healthineers, Beijing, China

Synopsis

Keywords: Placenta, fMRI, Gestational hypertension, perfusion, placenta, virtual magnetic resonance elastography

Motivation: Detecting placental dysfunction using MRI before placental macrovascular lesions by ultrasound may help the early identification of placental pathologic changes in gestational hypertension (GH).

Goal(s): To explore changes in placental elasticity and perfusion in GH and control groups using MRI.

Approach: Placental elasticity and perfusion were assessed using virtual magnetic resonance elastography (vMRE) and intravoxel incoherent motion (IVIM). The vMRE and IVIM parameters, MR morphologic parameters, and ultrasound and lab test results were compared between the two groups.

Results: Placental stiffness and perfusion fraction helped distinguish between the two groups, with no substantial differences in the other parameters.

Impact: Virtual magnetic resonance elastography and intravoxel incoherent motion can quantify placental elasticity and circulation at the microscopic level, and are superior to the ultrasound parameters, in gestational hypertension. They may serve as a vital noninvasive supplement to assess placental dysfunction.

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