Keywords: Susceptibility/QSM, Software Tools, Susceptibility source separation, Atlas, Iron imaging, Myelin imaging
Motivation: Abnormal iron and myelin distributions are associated with neurodegenerative diseases. An advanced susceptibility mapping technique, χ-separation, can disentangle paramagnetic iron and diamagnetic myelin contributions in quantitative susceptibility mapping.
Goal(s): In this study, a normative χ-separation atlas is created from 106 healthy volunteers.
Approach: To this end, individual χ-separation maps were registered to a common space and averaged across subjects.
Results: The resulting χ-separation atlas reflects well-known iron and myelin-rich structures in the brain. The analysis based on regions of interest revealed distinct characteristics of normative para- and diamagnetic susceptibility profiles throughout subcortical nuclei, thalamic nuclei, and white matter fibers.
Impact: Our χ-separation atlas would be utilized as a reference for imaging susceptibility in the brain and may assist in accurate localization of targets for intervention such as deep brain stimulation or high-intensity focused ultrasound.
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