Keywords: Susceptibility/QSM, Quantitative Susceptibility mapping, Electrical Properties Tomography, EPT, fMRI, fQSM, fQCM
Motivation: Quantitative susceptibility mapping (QSM), electrical conductivity mapping (EPT) and fMRI show promise in characterising neurodegenerative diseases but each currently needs a separate time-consuming acquisition.
Goal(s): To develop a single, rapid acquisition for simultaneous structural and functional QSM and EPT, providing multi-modal contrasts to facilitate development of biomarkers for neurological diseases.
Approach: We developed a multi-echo 2D EPI sequence with 1.3 mm isotropic resolution and 4.02 s TR enabling acquisition of 70 timepoints in 6 min 15 s. We optimised QSM, EPT and fQSM reconstruction pipelines.
Results: We obtained high-quality structural QSM and EPT, alongside fMRI and fQSM activations from a visual stimulus.
Impact: Demonstrating that this efficient multi-echo EPI acquisition rapidly produces high-quality simultaneous QSM, fQSM and EPT reconstructions alongside conventional T2*-weighted, SWI and fMRI contrasts in 6 min 15 s will allow it to be incorporated into clinical studies of neurodegenerative diseases.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords