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Abstract #0198

Abdominal Foundation Model: Bootstrapping artificial intelligence for MRI organ volume biomarker analysis in ADPKD

Chenglin Zhu1, Xinzi He2, Zhongxiu Hu1, Hreedi Dev1, Dominick J. Romano1, Arman Sharbatdaran1, Anna Prince1, Andrea Soto Figueroa1, Sophie J. Wang1, Hui Yi Ng He1, Jon D. Blumenfeld3, and Martin R. Prince1,4
1Weill Cornell Medicine, New York City, NY, United States, 2Cornell University and Cornell Tech, New York City, NY, United States, 3The Rogosin Institute, New York City, NY, United States, 4Columbia University Vagelos Collage of Physicians and Surgeons, New York City, NY, United States

Synopsis

Keywords: Kidney, Segmentation, ADPKD

Motivation: Abdominal organ volumes are critical MRI biomarkers in many diseases including autosomal dominant polycystic kidney disease.

Goal(s): We aim to develop a segmentation model with an enhanced ability to generalize across various abdominal organs and MR pulse sequences.

Approach: We construct a multi-modality abdominal foundation model expanding upon our existing ADPKD kidney model which adapts to diverse organs and tissues with minimal new training data.

Results: The model was trained using a model-in-loop methodology and evaluated against radiologist benchmarks, yielding an impressive Dice score of 0.94 for in-distribution sequences and 0.73 for organ segmentations on out-of-distribution sequences.

Impact: This foundational model can seamlessly integrate into clinical workflows, utilizing routine cases to enhance its performance and extending its application to additional organs and tissues. This advance also marks a significant step toward the automation of MRI reporting.

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