(ISMRM 2024) Estimating diffusion fractional anisotropy of disease in patients with advanced prostate and breast cancers. A single-center study.
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Abstract #0201

Estimating diffusion fractional anisotropy of disease in patients with advanced prostate and breast cancers. A single-center study.

Sheng Yu1, Antonio Candito1, Konstantinos Zormpas-Petridis 1,2, Ana Ribeiro1,3, Georgina Hopkinson3, Jessica M Winfield1,3, Nina Tunariu1,3, Christina Messiou1,3, Dow-Mu Koh1,3, and Matthew David Blackledge1
1Institute of Cancer Research, London, United Kingdom, 2Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy, 3The Royal Marsden NHS Foundation Trust, London, United Kingdom

Synopsis

Keywords: Cancer, Whole Body, Metastasis, Fractional Anisotropy

Motivation: Whole-body diffusion-weighted imaging in oncology assumes isotropic diffusion therefore that data probing the directional dependence of diffusion in body cancer applications is scarce.

Goal(s): To report the distribution of fractional anisotropy (FA) values in metastatic bone disease for a cohort of patients who underwent multi-directional diffusion weighted imaging.

Approach: Deep learning was used to auto-segment metastatic lesions; FA values are calculated for each segmented region and the distributions reported.

Results: FA distributions from 85 patients with metastatic disease (50 prostate, 33 breast) are reported and are deemed to be low (mean FA range breast group: 0.2179 - 0.3132; prostate group: 0.2866 - 0.3717).

Impact: We have conducted diffusion tensor imaging analysis for whole body DWI data and carried out the first bone lesion FA comparison study. This work provides a rationale for choice of diffusion-weighting gradient schemes in clinical imaging.

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Keywords

diffusion