Abstract #0202

Predicting Disease-Free Survival by DWI and DCE MRI Scores for Breast Cancer Patients with Neoadjuvant Systemic Treatment

Rie Ota¹, Masako Kataoka², Mami Iima², Maya Honda³, Aika Okazawa², Mizue Suzuki¹, Shotaro Kanao¹, Takeshi Kubo¹, Yosuke Yamada⁴, Yasuhide Takeuchi⁴, Masahiro Takada⁵, and Yuji Nakamoto²

¹Department of Radiology, Tenri Hospital, Nara, Japan, ²Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University graduate school of medicine, Kyoto, Japan, ³Department of Diagnostic Radiology, Kansai Electric Power Hospital, Osaka, Japan, ⁴Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan, ⁵Department of Breast Surgery, Kyoto University Hospital, Kyoto, Japan

Synopsis

Keywords: Breast, Breast

Motivation: MRI is expected to be a new surrogate marker of prognosis that can replace pathological complete response (pCR) for breast cancer patients who underwent neoadjuvant systemic treatment (NST).

Goal(s): MRI is expected to be a new surrogate marker of prognosis that can replace pathological complete response (pCR) for breast cancer patients who underwent neoadjuvant systemic treatment (NST)

Approach: Survival analysis was performed for disease-free survival using Kaplan-Meier method.

Results: DWI score after NST of breast cancer was associated with DFS, in particular triple-negative, HER2-positive, and luminal-HER2 subtype.

Impact: The DWI / kinetic score obtained from MRI after neoadjuvant systemic treatment (NST) were associated with disease-free survival (DFS), especially among triple-negative, HER2-positive, and luminal/HER2 subtype. The DWI score may be a biomarker for prognosis of breast cancer patients.

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