Keywords: Hyperpolarized MR (Non-Gas), Metabolism
Motivation: Fructose intake has increased 80-times over the past century, although the effect of this increase in the body remains unclear.
Goal(s): To assess the metabolic flux of fructose at different metabolic states (fed vs fasted) for future human studies.
Approach: Fed or fasted mice were injected with hyperpolarized fructose to observe metabolic flux.
Results: Fed mice showed the formation of glucose (gluconeogenesis) by F1P, while fasted mice metabolized the fructose to obtain energy.
Impact: The results pressented have significant implications for the understanding of fructoylsis and provides a translational metabolic imaging strategy for future human studies.
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