Keywords: Data Processing, Elastography
Motivation: MR-Elastography and diffusion-MRI represents complementary modalities with mechanical-and-structural information of the brain. Structural-connectomes alone lack tract-integrity information. Tissue viscoelastic-measures can provide valuable insights for tract-integrity when combined with connectomes.
Goal(s): To aid the studies with neurodegeneration(HIV/CSVD), an analytical approach to combine viscoelastic-measures with diffusion-tractography is proposed which shows promise in targeted-analysis of functionally-defined-networks.
Approach: For 14 functionally-defined brain-networks, viscoelastic measures from MRE are mean-sampled with the dMRI derived tracts. Then, the significantly-affected viscoelastic alterations are studied in-accord with cognitive-changes.
Results: In a cohort of HIV-CSVD, by MRE-Tract-Integrity analysis, we reported significantly affected network connectivity that follows the cognitive decline(p<0.05) in processing-speed and motor-skills.
Impact: The MRE-Tract-Integrity analysis enables us to study the missing mechanical properties of the structural connections from diffusion-tractography. This will help researchers performing targeted cognitive performance analysis with brain connectivity aided with mechanical basis which is a prominent marker for neural-change.
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